Table 2.
Viral load and resistance profiles of children with virological failure (VL > 1000 copies/mL)
| Variables | n/N tested | % | % |
|---|---|---|---|
| Viral load (VL) | |||
| VL ≥ 3 log10 | 320/498 | 64 | |
| 3 log10 ≤ VL ≤ 3.7 log10 | 120/320 | 37.5 | |
| 3.7 log10 < VL ≤ 4 log10 | 40/320 | 12.5 | |
| 4 log10 < VL ≤ 4.7 log10 | 100/320 | 31.25 | |
| 4.7 log10 < VL ≤ 5 log10 | 27/320 | 8.44 | |
| 5 > VL log10 | 33/320 | 10.31 | |
| Median VL = 4 log10 | |||
| Genotypes performed | 304/320 | 95 | |
| Frequency of drug-resistant virus | |||
| Resistance to at least one ART | 263/304 | 86.5 | |
| Resistance to NRTIs only | 5/263 | 1.9 | |
| Resistance to NNRTIs only | 60/263 | 22.8 | |
| Resistance to NRTIs+NNRTIs | 197/263 | 74.9 | |
| Resistance to NRTIs+NNRTIs+PIs | 1/263 | 0.4 | |
| Frequency of drug resistance to the different drugs | |||
| AZT | 90/263 | 34.22 | |
| d4T | 93/263 | 35.36 | |
| 3TC/FTC | 195/263 | 74.14 | |
| ABC | 165/263 | 62.73 | |
| ddI | 18/263 | 6.84 | |
| TDF | 43/263 | 16.34 | |
| EFV | 238/263 | 90.49 | |
| NVP | 253/263 | 96.19 | |
| ETRa | 125/263 | 47.52 | |
| RPVa | 136/263 | 51.71 | |
| Predicted resistance to the current regimen (3 drugs) | |||
| No resistance | 5/263 | 1.9 | |
| 1 out of 3 drugs | 66/263 | 25.09 | |
| 2 out of 3 drugs | 106/263 | 40.3 | |
| 3 out of 3 drugs | 86/263 | 32.69 | |
aDrug not given in the current ART regimen