Table 3.

Bone histomorphometric parameters in the zoledronate and control groups

Parameter	Control Baseline	Control 12 mo	Changes,a Absolute/%	Zoledronate Baseline	Zoledronate 12 mo	Changes,a Absolute/%	P Value Transplant	P Value Zoledronate versus Control	P Value Interaction
BV/TV, %	24.7±6.5	25.3±8.6	0.6/2.4	24.4±6.3	20.1±5.9	−4.3/−17.6	0.42	0.30	0.22
Tb.Sp, μm	393±155	429±169	36/9.2	387±106	541±185	154/39.8	0.003	0.24	0.06
Tb.Th, μm	125±24	134±35	9/7.2	120±27	128±22	8/6.7	0.12	0.53	0.98
Tb.N, per mm	2.1±0.6	1.9±0.4	−0.1/−4.8	2.0±0.4	1.5±0.3	−0.5/−25	<0.001	0.20	0.14
OV/BV, %	7.0±6.2	6.8±9.2	−0.2/−2.9	9.9±13.3	2.9±3.1	−7/−70.7	0.07	0.82	0.09
OS/BS, %	34.1±20.1	28.7±18.4	−5.4/−15.8	39.1±19.5	19.2±14.4	−19.9/−50.9	0.002	0.64	0.06
O.Th, μm	9.7±4.8	10.4±5.3	0.7/7.2	10.1±5.3	8.0±3.5	−2.1/−20.8	0.56	0.36	0.24
Ob.S/BS, %	7.9±6.4	7.2±5.7	−0.7/−8.9	12.4±10.2	5.0±4.6	−7.4/−59.7	0.002	0.48	0.27
Oc.S/BS, %	1.5±1.2	0.5±0.5	−1.0/−66.7	2.5±1.9	0.4±0.4	−2.1/−84	<0.001	0.18	0.06
ES/BS, %	11.1±6.1	4.6±2.4	−6.5/−58.6	13.0±6.5	4.0±2.2	−9/−69.2	<0.001	0.57	0.23
BFR, μm3/μm2 per day	0.06±0.06	0.04±0.03	−0.02/−33.3	0.07±0.09	0.04±0.03	−0.03/−42.9	0.04	0.83	0.71
Mlt, d	225.2±245.8	198.1±228.7	−27.1/−12	191.5±226.8	170.7±343.3	−20.8/−10.9	0.66	0.66	0.99
Ct.Th, μm	735±183	1105±446	370/50.3	714±171	1234±385	520/72.8	<0.001	0.62	0.24
Ct.Po, %	8.0±3.4	5.1±3.0	−2.9/−36.2	7.5±2.8	5.8±3.2	−1.7/−22.7	0.001	>0.99	0.32

P values are derived from a linear mixed model. BV/TV, bone volume/tissue volume; Tb.Sp, trabecular separation; Tb.Th, trabecular thickness; Tb.N, trabecular number; OV/BV, osteoid volume/bone volume; OS/BS, osteoid surface; O.Th, osteoid thickness; Ob.S/BS, osteoblasts/bone surface; Oc.S/BS, osteoclasts/bone surface; ES/BS, erosion surface/bone surface; BFR, bone formation rate; Mlt, mineralization lag time; Ct.Th, cortical thickness; Ct.Po, cortical porosity.

^aChanges according to groups.