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. 2018 Apr 29;103(2):227–232. doi: 10.1136/bjophthalmol-2017-311782

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0

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A close-up of three different stages of retinal pigment epithelium (RPE) integrity overlying drusen. The top image shows a three-dimensional (3D) representation of the segmented RPE layer, the corresponding colour fundus photography in the centre and two B-scans of the corresponding region below (width of the B-scans and images above ~1 mm). (1) indicates a large soft druse showing focal lesions within the depolarisation signal, (2) a calcified druse with a fill-out with depolarising material and an irregular RPE shape, and (3) a concave-shaped druse with adjacent RPE lesion, which has an interesting form shown in 3D from another perspective in the bottom left image.