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. 2019 Feb 1;33(3-4):150–165. doi: 10.1101/gad.320481.118

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© 2019 Bhatt et al.; Published by Cold Spring Harbor Laboratory Press

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Figure 5. — Autophagy deficiency alters lipid metabolism. (A,B) Representative Oil Red O staining of KL tumors (A) and KL and KP TDCLs in RPMI and HBSS starvation (B). (C, left) Quantification of Oil Red O staining of TDCLs from ImageJ. (Right) Quantification of Oil Red O staining normalized to RPMI to show significant reduction of LDs in Atg7^−/− KL TDCLs in starvation. (D) Comparison of lipids between Atg7^+/+ and Atg7^−/− cells in nutrient-rich conditions obtained by LC-MS. (E) [U¹³C6] glucose tracer labeling to FAs of TDCLs in steady state. (F) Cell proliferation rate in the absence or presence of 50 µM FA synthase inhibitor fasnall in a nutrient-rich RPMI condition. For all of the graphs, the error bar indicates ±SEM. (*) P < 0.05; (**) P < 0.01; (***) P < 0.001. See also Supplemental Figure S7.