Databases searched included Ovid MEDLINE, EMBASE, The Cochrane Central Register of Controlled Trials, and The Cochrane Database of Systematic Reviews from January 1999 and December 2017. Reference lists from published narrative review articles and systematic reviews were further reviewed to identify additional studies. The following MeSH terms and free words were used: “delirium prevention,” “multicomponent intervention,” “non-pharmacological intervention” and “Hospital Elder Life Program.” Utilizing our systematic literature search strategy, 3275 articles were found. Of these, 3202 were excluded based on our screening criteria for relevance, language, age range, or non-human study subjects; full-text articles of the remaining 73 studies were retrieved for further assessment according to the inclusion criteria. A total of 14 studies were included in meta-analysis and an additional 30 were included as cost-savings studies, methodological papers, and qualitative studies.