Table 2.
Concentration Response and Detergent Sensitivity of FP HTS Hits
| AC8-Nt pIC50 | AC8-C2b pIC50 | ||||
|---|---|---|---|---|---|
| cLogPa | 0% Triton | 0.01% Triton | 0% Triton | 0.01% Triton | |
| CDZ | 10.3 | 5.55 ± 0.01 | 5.54 ± 0.07 | 5.5b | 5.01 ± 0.05 |
| TFP | 4.9 | 4.4 ± 0.6 | c | ||
| alexidine | 4.3 | 5.67 ± 0.01 | 5.85 ± 0.03 | 5.23 ± 0.07 | 5.23 ± 0.06 |
| benzethonium | 6.1 | 4.57 ± 0.02 | 4.3 ± 0.2 | ||
| otilonium | 6.3 | 4.78 ± 0.01 | 4.48 ± 0.05 | ||
| thonzonium | 8.1 | 5.27 ± 0.02 | 5.04 ± 0.06 | 5.0b | 4.9b |
| cetrimonium | 6.2 | 4.94 ± 0.02 | 4.94 ± 0.03 | ||
| domiphen | 6.1 | 4.84 ± 0.02 | 4.81 ± 0.02 | ||
a
Retrieved from ZINC15.26
Data represent the mean of three independent experiments ± SEM.
b
SEM not calculated.
c
Not determined.