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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Free Radic Biol Med. 2018 Nov 17;131:98–114. doi: 10.1016/j.freeradbiomed.2018.11.017

Figure 10. Pretreatment with Ginseng or DMF improves the neurobehavioral outcomes over 7 days after HI, but not under Nrf2 deficiency.

Figure 10.

Neurological deficits score (A and C) and locomotor activity (B and D) were performed at 3 and 7 days after HI). Pretreatment with Ginseng or DMF ameliorated neurological deficits score at 3 and 7 days after HI in WT mice, but not in Nrf2−/− mice, whereas Nrf2 deficiency exacerbated neurological deficits score at 7 days after HI. There was no significance in locomotor activity among groups except that pretreatment with Ginseng significantly improved the locomotor activity in WT mice at 7 days after HI. Pretreatment with Ginseng or DMF ameliorated sensorimotor deficits at 3 and 7 days after HI in WT mice, but not in Nrf2−/− mice, revealed by cylinder test. n = 7–11 per group for 3 days, n = 7–10 per group for 7 days. *P < 0.05, #P < 0.05.