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. Author manuscript; available in PMC: 2020 Feb 15.
Published in final edited form as: Eur J Med Chem. 2018 Dec 21;164:179–192. doi: 10.1016/j.ejmech.2018.12.047

Figure 4.

Figure 4.

SAR design for hit 11. Sites for structural variation include the C5 amino group (subtype 12), the C4 carboxamide moiety (subtypes 13—16), and the C2 carboxamide phenyl ring (subtype 19). In addition, 4,5-cyclized analogues (subtype 17) and 2,3-cyclized analogues (subtype 18) are also designed.