Table 1.
Evaluation of flow properties of fillers, uniformity of mass of drug-free capsules
| Filler | F (s) | Α (°) | CI (%) | HR | BD (g/cm3) | TD (g/cm3) | Amount of filling (%) | RSD (%) of UM | |
| I | II | ||||||||
| Pharmatose 200M | N/A | N/A | 28.57 | 1.40 | 0.50 | 0.70 | 100.0 107.5 115.0 |
1.40 1.76 0.99 |
1.71 1.52 1.28 |
| Pharmatose DCL11 |
3.6 | 30 | 13.33 | 1.15 | 0.65 | 0.75 | 100.0 107.5 115 |
4.65 1.43 2.35 |
2.41 4.68 2.00 |
| DiCafos A60 |
3.3 | 28 | 12.34 | 1.14 | 1.35 | 1.54 | 100.0 107.5 110.0* |
4.10 1.43 1.21 |
1.94 2.84 1.04 |
A, angle of repose; BD, bulk density; CI, Carr’s index; F, flowability; HR, Hausner ratio; N/A, not applicable; NS, normal saline; TD, tapped density; UM, mass uniformity; I and II, batches.
*Lower amount of filling was used because of better flow properties of Dicafos.