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. 2019 Jan 29;10:3. doi: 10.3389/fphar.2019.00003

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Copyright © 2019 Kunzelmann, Ousingsawat, Cabrita, Doušová, Bähr, Janda, Schreiber and Benedetto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Accumulation of mucus in airways of TMEM16A^−/− mice. Mucus staining (PAS) in bronchi of wild type littermates (TMEM16Aflox/flox; TMEM16A^+/+) and mice with an airway epithelial-specific knockout of TMEM16A (FOXJ1-Cre-TMEM16Aflox/flox; TMEM16A^−/−). Strong accumulation of mucus in airway epithelial cells is observed in TMEM16A^−/− mice. Bars indicate 20 μm (Benedetto et al., 2019).