Table 7.
Diagnostic performances of both miR-215 and SCCA-IgM vs AFP for distinguishing HCC patients from LC patients
| Variables | Optimal cutoff | AUC | P-values | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) |
|---|---|---|---|---|---|---|---|---|
| AFP | >117 | 0.854 | <0.001* | 77.0 | 81 | 100 | 47.6 | 75.6 |
| miR-215 | >417 | 0.997 | <0.001* | 97.14 | 91 | 97.1 | 90 | 95.66 |
| SCCA-IgM | >95 | 0.932 | <0.001* | 92 | 98 | 97.9 | 92.5 | 95 |
Notes:
*
P-value is significant ≤0.05.
Abbreviations: AFP, alpha-fetoprotein; AUC, area under the curve; HCC, hepatocellular carcinoma; LC, liver cirrhosis; NPV, negative predictive value; PPV, positive predictive value; SCCA-IgM, squamous cell carcinoma antigen-IgM.