Table 6.
Mutations associated with rifaximin resistance
| No. | Strain name | MIC (mg/L) | rpoB mutation |
|---|---|---|---|
| 1 | Surabaya47 | 4 | S355Y, I741V, T2002M, Q2079K |
| 2 | Jayapura21 | 4 | V1125I, A2454V |
| 3 | Jayapura06 | 8 | L547F, K786R, I837V, A964T, V1275I, A1533S, P1623S, D1697N, G1908E, A2099T, S2640Y |
| 4 | Jakarta9 | 4 | I64V, L295I, S355Y, V657I, T1023I, S1197A, Q2042R, K2068R |
| 5 | Kupang10 | 4 | G523C, I832V, E877K, K1006E, E1528D, Q1666H, N1944S, A2255V, G2512S, S2619I, V2774M |
| 6 | Kupang23 | 4 | L169S, S355H, A693T, I837V, K854R, L977I, I1351T, N1999H, K2068R, Q2079K, S2415N, I2481V, V2528L, P2679S, M2696T |
| 7 | Kupang26 | 4 | L169A, S355H, I837V, L977I, N1999H, Q2079K, S2415N, A2472V, I2481V, V2528L, P2679S, M2696T |
| 8 | Kupang29 | 4 | K42R, I748V, T773I, A958T, E969D, S986G, A1025V, V1052I, V1122I, A2414V, S2619I |
| 9 | Kupang30 | 4 | S355H, S627N, I837V, A1025V, D1162N, K1165R, L1401I, R1711H, Q2079K, A2234T, D2380E |
| 10 | Kupang34 | 4 | S355H, A732V, I837V, V955I, L977I, V1028A, N1999H, K2068R, Q2079K, S2415N, I2481V, V2528L, P2679S, M2696T |
| 11 | Bangli42 | 4 | I141V, E163D, N642D, R954W, E996G, M1264I, E1407K, Y2275C, K2462E, V2469I, G2480R, T2539A |
| 12 | Bangli47 | 4 | L314F, E1151K, I1190T, R1711H, K2068R, Y2326C, K2418Q, V2528L, T2536A, F2537L, K2538S, K2557R, V2561M, A2570T, S2734G |
| 13 | Bangli64 | 4 | R63H, E162K, L295I, I336T, M667I, A735T, P816S, I837V, V867A, R973H, T975I, Q1010R, E1572Q, A1691V, A2346T, S2390G, G2491D, A2541V |
| 14 | Manado29 | 4 | D255N, P259S, A1168V, A1181V, A1533T, L1765F, V1939I, A1950T, L2328I, R2694H, I2824V |
| 15 | Manado31 | 8 | K307E, R984H, V1028A, A1533T, A2255V, Y2326C, A2494T |
| 16 | Merauke20 | 4 | K786R, A964T, R2313H, G2512S |
| 17 | Merauke21 | 4 | A1181V, G2180S, A2472T, P2545S, V2664M |
| 18 | Merauke27 | 4 | I140V, A1533T, S1701N, A2505T, V2664M |
| 19 | Merauke37 | 4 | S78P, P95H, M313L, K786R, A964T, L977F, E1014K, M1242I, D1379N, A1533S, G2180S, A2414T, R2477H, A2494T, I2730V |
| 20 | Kolaka72 | 4 | R274I, S355Y, V538I, T635A, R1248H, G2403S, A2541, N2602D, R2641K, D2788G |
| 21 | Kolaka79 | 4 | – |
| 22 | Kolaka96 | 4 | R708K, L982S, E1161K, N1709D, E2382K, V2469I, R2477Y, V2528L, T2536A, F2537L, K2538S, K2557R, V2561M, R2882K |
| 23 | Kolaka98 | 4 | P259S, A735T, S743A, I837V, T975S, A1025S, K1165R, D1379Y, K2068R, Q2079K, K2421R |
| 24 | Kolaka99 | 4 | L295I, S355Y, A473V, M1175I, R1711H, Q2079K, A2454V, P2612S, S2675G |
| 25 | Makasar31 | 8 | L295I, I336T, G615D, A735V, I837V, Q1010R, D1379Y, V1491I, H1985Y, V2237M, A2317V, D2380E, R2506C |
| 26 | Makasar45 | 4 | E1161K, A2414V |
| 27 | Makasar52 | 4 | E1161K, A2414V |
| 28 | Makasar55 | 4 | P931S, A1643M, A1950T, K2068R, D2380E |
| 29 | Medan56 | 4 | V303I, K1540N, A2414V, A2454V |
| 30 | Medan67 | 4 | A497T, A958T, N1598H, T2002M, R2313C, A2414V |
| 31 | Medan75 | 4 | I512V, M667I, A964V, T1402M, A2414V, E2599A, V2638I, S2791G |
| 32 | Padang42 | 4 | H153Y, P931S, H1985Y, E2183K, A2414V, E2604G |
| 33 | Pontianak44 | 4 | A487T, E969D, V1291I, A2255V, V2447I |
| 34 | Pontianak50 | 4 | S355Y, S627N, E969K, R1563K, M1627I, A1676V, S1794N, N1999H, V2037I, D2449N, A2459T, T2533M, M2696T, E2859G |
| 35 | Pontianak5 | 4 | V2802L |
| 36 | Surabaya283 | 4 | P259S, T440A, A497T, E1232D, N1944S, V2037I, I2428V, I2564V, Y2740H, K2889R |
| 37 | Surabaya304 | 8 | S78A, S355Y, K398R, V657I, E1486D, D2226S, L2328I, A2357V |
| 38 | Medan15 | 4 | A473V, Q991R, E1059G, S1197A, K2068R |
| 39 | Medan22 | 32 | I66V, L295I, S355Y, I586L, E655K, V657I, G1620S, A2541T, L2881I |
| 40 | Medan25 | 8 | V52I, I66V, E106G, V657I, A756V, D2380E, K2482R |
Note: S355Y means tyrosine replaced serine amino acid in the position 355.
Abbreviation: MIC, minimal inhibitory concentration.