Table 7.
Diagnostic accuracy of SERS assay vs frozen section compared to histology for the diagnosis of epithelial ovarian tumors in a subset of women (n=65)
| Performance | Haptoglobin by SERS* | Frozen section | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| Test | CA | Non-CA | Total | CA | Non-CA | Total |
|
| ||||||
| Positive | 35 | 4 | 39 | 37 | 0 | 37 |
| Negative | 2 | 24 | 26 | 0 | 28 | 28 |
| Total | 37 | 28 | 65 | 37 | 28 | 65 |
| 95% CI | 95% CI | |||||
| Lower | Upper | Lower | Upper | |||
| Sensitivity | 94.60% | 80.50% | 99.10% | 100% | 88.30% | 100% |
| Specificity | 85.70% | 66.40% | 95.30% | 100% | 85% | 100% |
| PPV | 89.70% | 74.80% | 96.70% | 100% | 88.30% | 100% |
| NPV | 92.30% | 73.40% | 98.70% | 100% | 85% | 100% |
| Accuracy | 90.80% | NA | NA | 100% | NA | NA |
Abbreviations: CA, cancer; NA, not applicable; NPV, negative predictive value; PPV, positive predictive value; SERS, surface-enhanced Raman spectroscopy.