. Author manuscript; available in PMC: 2019 Feb 5.

Published in final edited form as: Am J Surg Pathol. 2012 Jul;36(7):945–954. doi: 10.1097/PAS.0b013e318253a2d1

Table 4.

Receiver operator characteristic curve analysis for p16 intensity and staining in comparison to HR-HPV E6/7 analysis

Classification Variable	Area Under Curve (95% CI)			Optimal Cutoff
Classification Variable	R1	R2	R3	Cutoff Point	Average Sensitivity (95% CI)	Average Specificity (95% CI)
P16 IHC Maximum Tumor Intensity	0.9243 (0.8847, 0.9639)	0.9423 (0.9077, 0.9769)	0.9193 (0.8777, 0.9609)	2	94.94% (89.95%, 97.60%)	84.93% (74.24%, 91.85%)
P16 IHC Percent at Maximum Tumor Intensity	0.9412 (0.9084, 0.9741)	0.9590 (0.9301, 0.9879)	0.9295 (0.8881, 0.9710)	35%	87.98% (81.98%, 92.03%)	90.09% (80.49%, 95.34%)
H-Score	0.9491 (0.9183, 0.9799)	0.9570 (0.9288, 0.9852)	0.9318 (0.8919, 0.9716)	60	91.56% (85.93%, 95.07%)	90.41% (80.70%, 95.69%)