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. 2019 Jan 18;10(6):673–683. doi: 10.18632/oncotarget.26586

Figure 1. miR-194-5p is downregulated in paclitaxel-resistant ovarian cancer cell lines.

Figure 1

(A) Scheme for the establishment of two paclitaxel-resistant sublines, SKOV3ip1-TR and HeyA8-TR, derived from SKOV3ip1 and HeyA8, respectively. These cells were exposed to stepwise increases of paclitaxel until a concentration of 300 nmol/L. (B) In vitro survival assay of ovarian cancer cell lines upon paclitaxel treatment. Growth inhibitory effects of paclitaxel treatment were determined using an MTS assay. Experiments were performed in triplicate. Data are represented as mean ± SE and are obtained from three independent experiments. (C) miRNA microarray. List of miRNAs that exhibited increased (> 2-fold, red columns) or decreased (< 0.5-fold, green columns) expression in both paclitaxel-resistant sublines compared with their corresponding parental cell lines.