Table 1.

A list of reports showing roles of DDRs in MMPs production. A list of references showing DDRs-mediated MMPs upregulation are shown. Upreguated MMPs, references, cell types and requirement of collagen stimulation for MMPs upregulation are shown.

DDRs	Upregulated MMPs	References	Cell types	Requirement of collagen
DDR1	MMP-1	Ferri et al.28	human smooth muscle cells	No
	MMP-2 & MMP-9	Hou et al.30	mouse smooth muscle cells	No
		Ram et al.17	human glioma cells	No
		Park et al.31	human hepatocellular carcinoma	No
		Castro-Sanchez et al.32	MDA-MB231, ZR-75	Yes
	MMP-7	Roberts et al.29	human smooth muscle cells	ND
DDR2	MMP-1	Vogel et al.27	HT1080	Yes
		Ferri et al.28	human smooth muscle cells	No
	MMP-13	Xu et al.37	human chondrocytes	No
		Sunk et al.38	human chondrocytes	Yes
		Vonk et al.39	human chondrocytes	Yes
	MMP-14	Majkowska et al.45	human skin fibroblasts	Yes
			human rheumatoid synovial cells

^*not determined