Table 2.

Class II bacteriocins produced by bacteria originally isolated from the human gut.

Class II (unmodified or cyclic)
Group	Distinctive feature	Bacteriocin from human gut isolate	Gut Producer first isolated from human	Activity against	Reference
IIa peptides (pediocin PA-1-like bacteriocins)	Conserved YGNGV motif (N represents any amino acid)	Bac43	Enterococcus faecium VRE82	E. faecalis, E. faecium, Enterococcus hirae, Enterococcus durans, and L. monocytogenes	122
		Bacteriocin RC714	E. faecium strain RC714	E. faecalis, E. faecium, L. monocytogenes, Listeria innocua, Listeria murrayi, Listeria grayi, Lactobacillus paracasei, Lactobacillus plantarum, Leuconostoc sp., and Pediococcus pentosaceus	124
		Bacteriocin 31	E. faecalis YI717	E. hirae 9790, E. faecium, and L. monocytogenes	155
IIb peptides	Two unmodified peptides are required for activity	ABP-118	Lactobacillus salivarius UCC-118	L. monocytogenes	127
		Acidocin J1132	Lactobacillus acidophilus JCM1132	Lactobacillus sp	126
		Gassericin T	Lactobacillus gasseri SBT 2055	Lactobacillus delbrueckii subsp. bulgaricus	130
		Lactacin F	Lactobacillus johnsonii	Lactobacillus sp, E. faecalis	156
IIc peptides	Cyclic peptides	Gassericin A	L. gasseri LA39	Bacillus, Clostridium, Lactobacillus spp, Lactococcus lactis, Leuconostoc mesenteroides, Listeria spp, Pediococcus cerevisiae, S. aureus, Streptococcus agalactiae	157
		Reutericin 6	Lactobacillus reuteri LA 6	L. acidophilus, L. delbrueckii subsp. bulgaricus and L. delbrueckii subsp. lactis	158
		AS-48	E. faecalis AS-48	Gram-positive and Gram-negative	159
IId peptides	Unmodified, linear, non-pediocin-like, single-peptide bacteriocins	Microcin S	E. coli G3/10	E. coli G3/10	136
		Rhamnosin A	Lactobacillus rhamnosus strain 68	Micrococcus lysodeikticus ATCC 4698	138
		Bac32	Vancomycin-resistant E. faecium (VRE) 200	E. faecium, E. hirae, and E. durans	139

Examples of Class II (IIe) have not yet been described from human gut isolates. Classification of bacteriocins is based on Cotter et al, 2013.