Table 2. Phase 2 demographics and neuropsychological test performance.
| Patient | Control | ||||||
|---|---|---|---|---|---|---|---|
| Mean | s.d. | Mean | s.d. | Mean difference (95%CI) | p | d | |
| Demographics | |||||||
| Age | 46.0 | 11.9 | 44.8 | 16.5 | -1.11 (-9.19,6.80) | 0.785 | |
| Gender (%F) | 75% | - | 65% | - | χ2 = 0.642 | 0.423 | - |
| Premorbid IQ | |||||||
| NART | 117.9 | 7.9 | 117.5 | 9.2 | -0.41 (-4.79,3.93) | 0.851 | -0.05 |
| Verbal Memory | |||||||
| Digit Span forwards | 6.8 | 1.4 | 6.6 | 1.5 | -0.16 (-0.59,0.92) | 0.676 | -0.12 |
| AVLT total recall (trails 1–5) | 46.9 | 10.4 | 49.4 | 7.9 | 2.46 (-1.78,6.1) | 0.281 | 0.25 |
| AVLT recall after interference (A6) | 9.6 | 3.3 | 10.7 | 2.4 | 1.06 (-0.30,2.36) | 0.125 | 0.34 |
| AVLT delayed recall (A7) | 9.1 | 3.2 | 10.7 | 2.7 | 1.51 (0.06,3.01) | 0.041* | 0.49 |
| AVLT recognition (list A hits) | 12.4 | 2.5 | 12.9 | 2.3 | 0.44 (-0.86,1.65) | 0.477 | 0.18 |
| Visual Memory | |||||||
| Visual Patterns Test total score | 22.5 | 5.9 | 23.5 | 6.4 | 1.03 (-2.17,4.20) | 0.559 | 0.17 |
| Spatial Memory | |||||||
| Spatial Span forwards | 5.1 | 1.5 | 5.6 | 1.7 | 0.50 (-1.35,0.36) | 0.229 | 0.33 |
| Spatial Span backwards | 4.9 | 1.2 | 5.0 | 1.2 | 0.08 (-0.61,0.71) | 0.828 | 0.06 |
| Executive Function | |||||||
| Verbal Fluency (total correct) | 39.3 | 10.6 | 44.8 | 12.2 | 5.50 (-0.19,11.06) | 0.075 | 0.50 |
| Stroop Colour-Word trial (total correct) | 37.9 | 12.4 | 46.9 | 11.8 | 9.02 (2.44,15.35) | 0.006* | 0.74 |
| Stroop Interference score | 2.5 | 8.3 | 2.8 | 9.1 | -0.24 (-5.04,4.92) | 0.926 | -0.03 |
| Digit Span backwards | 5.0 | 1.3 | 5.4 | 1.2 | 0.42 (-0.23,0.99) | 0.186 | 0.34 |
| Trail Making Test B | 63.9 | 37.1 | 55.2 | 20.1 | -9.15 (-21.69,2.97) | 0.236 | 0.31 |
| Trail Making Test B-A | 32.9 | 23.1 | 33.1 | 19.2 | 0.17 (-9.29,11.16) | 0.977 | -0.01 |
| Psychomotor Speed | |||||||
| Trail Making Test A | 30.6 | 17.4 | 22.2 | 6.4 | -8.47 (-15.00,-3.30) | 0.027* | 0.65 |
| Digit-Symbol Substitution (1/min) | 35.2 | 9.5 | 42.7 | 9.8 | 7.52 (2.78,13.25) | 0.004* | 0.78 |
| Digit-Symbol Copy (1/min) | 67.5 | 18.9 | 82.7 | 19.7 | 15.24 (5.22,24.70) | 0.007* | 0.80 |
| Digit-Symbol Scanning (1/min) | 37.9 | 8.6 | 45.5 | 13.6 | 7.55 (1.69,14.24) | 0.034* | 0.67 |
| Stroop Colour Reading (total correct) | 84.2 | 25.0 | 104.3 | 14.6 | 20.06 (11.07, 29.09) | 0.001* | 0.98 |
| Stroop Colour Naming (total correct) | 61.6 | 17.0 | 76.4 | 11.3 | 14.71 (8.01,21.52) | 0.001* | 1.02 |
*Statistically significant result