Table 3.
Peptide-specific T-cells (Dimer Assay) population and T-cell cytokine responses (ELISPOT Assay) after being stimulated with peptides, in patients with no expression of MAGED4B/FJX1, patients with either MAGED4B or FJX1 expression and patients with both MAGED4B and FJX1 expression. The percentage of peptide-specific population shown in dimer experiment was after subtracting the mock-dimer control (range: 0.0% – 3.0%).
| Antigen expression (IHC) |
% Population of peptide specific T-cells (Dimer) |
|||||
|---|---|---|---|---|---|---|
| Patient no. | MAGED4B | FJX1 | FluM | MAGED4B | FJX1 | Responses upon peptide stimulation (ELISPOT) |
| 195635 | - | - | 2.8 | 0.2 | 0.4 | N |
| 045497 | - | + | 0.8 | 0.9 | 3.5 | Y |
| 145091 | - | + | 3.9 | 12.7 | 1.5 | N |
| 156479 | - | + | 1.2 | 0.0 | 1.4 | Y |
| 205945 | - | + | 6.9 | 4.1 | 1.0 | N |
| 065217 | - | + | 1.8 | 4.2 | 3.4 | Y |
| 105203 | - | + | 8.8 | 9.3 | 3.6 | Y |
| 011815 | + | - | 6.9 | 4.1 | 1.0 | N |
| 055593 | + | + | 0.0 | 2.7 | 4.0 | Y |
| 135443 | + | + | 4.2 | 5.5 | 5.4 | Y |
| 060616 | + | + | 2.5 | 2.0 | 5.1 | N |