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. 2019 Feb 5;14(2):e0211432. doi: 10.1371/journal.pone.0211432

Fig 8. R1-subtype foot domain glycerol binding site is not present in R2-subtype tail fiber NTF.

Fig 8

Glycerol binding pocket with all residues within 6 Å of the ligand highlighted. (left) R1-NTF surface coulombic map with glycerol ligand (black, colored by element); (right) Surface coulombic map of analogous aligned region in the R2-NTF foot. Comparison of the binding pocket between the R1-NTF and R2-NTF foot domains suggests feasible binding of glycerol to the R1-NTF only. Glycerol is capable of binding carbohydrate pockets in conformations similar to those used by sugar ligands. The presence of glycerol could indicate that this site is involved in R1-type specific tail fiber interactions with target strain LPS.