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. 2019 Jan 24;15(1):e1007913. doi: 10.1371/journal.pgen.1007913

Fig 10. Dynamic model for CUC2-induced boundaries patterning and growth during tooth morphogenesis.

Fig 10

(A) CUC2 sets leaf margin patterning by: (i) modifying CUC3 expression pattern (ii) activating KLUH expression (iii) and creating auxin transport polarity convergence points through a cell-autonomous mechanism that builds-up high auxin response foci. In turn, high auxin response spatially restricts CUC2 and CUC3 expression. (B) Once the pattern is established, CUC2 becomes dispensable for tooth outgrowth (light pink). KLUH and CUC3 are expressed in the sinus and they both modulate auxin response that is the main driver for tooth outgrowth. (C) In a later phase, KLUH is not expressed anymore. However, KLUH promotes auxin response either indirectly or by the production of a persistant signal (light blue). CUC3 promotes auxin response. Whether KLUH and CUC3 control growth events independently of auxin is still unknown (dashed line).