Table 3. Net Reclassification Improvement.

Stroke or Systemic Embolism (Number of Patients with Events)
1-year Risk of S/SEE Predicted by CHA2DS2-VASc Model	1-year Risk of S/SEE Predicted by ABC-Stroke Model
		<1%	1–2%	>2%
	<1%	1	1	1
	1–2%	14	37	41
	>2%	3	12	29
Stroke or Systemic Embolism (Number of Patients with No Events)
1-year Risk of S/SEE Predicted by CHA2DS2-VASc Model	1-year Risk of S/SEE Predicted by ABC-Stroke Model
		<1%	1–2%	>2%
	<1%	517	113	5
	1–2%	1868	2870	1188
	>2%	124	604	966
Risk Score Comparison
ABC-Stroke vs. CHA2DS2-VASc Risk Scores			Percent Reclassification (n)
Correctly Upclassified			31.9% (43)
Incorrectly Downclassfied			20.9% (29)
Incorrectly Upclassified			15.8% (1306)
Correctly Downclassified			31.4% (2596)
Net Reclassification Improvement at 3 years			25.2% (95% CI, 13.1% – 46.1%)
Major Bleeding (Number of Patients with Events)
1-year Risk of Major Bleeding Predicted by HAS-BLED Model	1-year Risk of Major Bleeding Predicted by ABC-Bleeding Model
		<1%	1–2%	>2%
	<1%	0	0	0
	1–2%	1	6	3
	>2%	0	32	209
Major Bleeding (Number of Patients with No Events)
1-year Risk of Major Bleeding Predicted by HAS-BLED Model	1-year Risk of Major Bleeding Predicted by ABC-Bleeding Model
		<1%	1–2%	>2%
	<1%	0	0	0
	1–2%	287	512	147
	>2%	290	1460	4268
Risk Score Comparison
ABC-Bleeding vs. HAS-BLED Risk Scores			Percent Reclassification (n)
Correctly Upclassified			1.2% (3)
Incorrectly Downclassfied			13.1% (33)
Incorrectly Upclassified			2.1% (147)
Correcty Downclassified			29.2% (2037)
Net Reclassification Improvement at 3 years			13.8% (95% CI, 8.0% – 22.8%)

CI indicates confidence interval; S/SEE, stroke or systemic embolic event.