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. Author manuscript; available in PMC: 2019 Feb 5.
Published in final edited form as: Phys Med Biol. 2015 Feb 10;60(5):1919–1944. doi: 10.1088/0031-9155/60/5/1919

Figure 1.

Figure 1.

TOF PET principle (schematic drawing). When assuming perfect collinearity of annihilation photons, each registered coincidence event defines a line of response (LOR) connecting the two responding detectors. The gray value of each pixel encodes its probability to contain the origin of the registered event. In TOF PET, measurement of the arrival time difference of the annihilation photons (Δt) allows one to estimate the location of the registered event on its LOR much more accurately than in native PET, where the event is statistically spread over its entire LOR.