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. 2019 Feb 4;151(2):174–185. doi: 10.1085/jgp.201711884

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© 2019 Gamal El-Din et al.

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Figure 3. — Truncation of the C-terminal tail accelerates the early phase of inactivation. (A) Cells were held at −180 mV, and 50-ms depolarizing pulses were applied in 10-mV steps from −180 mV to +50 mV. Top: Comparison of Na_VAbΔ40 inactivation during the pulse (red) to Na_VAb/WT (black) during a depolarizing pulse from a holding potential of −180 mV to −80 mV. Bottom: Time constant of the decay of current during depolarizations to the indicated potentials for Na_VAbΔ40 (red, n = 4) and Na_VAb/WT (black, n = 7). The Na_VAb/WT inactivation time constants were adapted from previous work (Gamal El-Din et al., 2013) for ease of comparison. (B) Time to peak current for Na_VAbΔ40 (red) and Na_VAb/WT (black; n = 5–7). (C) Top: Representative normalized current traces during a depolarizing pulse from a holding potential of −180 mV to −80 mV. Time constant of inactivation for Na_VAbΔ40 (red), Na_VAbΔ28 (blue), Na_VAbΔ10 (green), Na_VAbΔ7 (gold), and Na_VAbΔ3 (gray); n = 4–11. The inactivation time constants were estimated using the equation y_o + A(exp(−t/τ). (D) Time to peak current of the C-terminal truncated constructs, color coded as in C (n = 6–7). Error bars represent SEM.