Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 4;151(2):174–185. doi: 10.1085/jgp.201711884

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Gamal El-Din et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 4. — Truncation of the C-terminal tail abolishes late use-dependent inactivation. (A) Representative current traces showing late use-dependent inactivation of Na_VAb WT (black) and loss of late use-dependent inactivation in Na_VAbΔ40 (red). (B) Peak inward currents recorded during each pulse in trains of depolarizations at 0.2 Hz and normalized to the current produced by the first depolarization of the train for Na_VAbΔ40 (7 ms, red, n = 7; 100 ms, pink, n = 5) and Na_VAb/WT (7 ms, black, n = 7; 100 ms, gray n = 11). (C) Top: Representative currents recorded during each pulse in trains of depolarizations at 1 Hz. Bottom: Normalized currents during each depolarizing pulse for Na_VAbΔ40 (red, n = 3) and Na_VAb/WT (black, n = 5). (D) Top: Representative currents for Na_VAb40 (red) during 100-ms conditioning pulses followed by 20-ms test pulses. Bottom: Voltage dependence of inactivation for Na_VAb40 (red) compared with Na_VAb/WT (black), as reported previously (Lenaeus et al., 2017). Error bars represent SEM.