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. 2019 Feb 4;151(2):174–185. doi: 10.1085/jgp.201711884

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© 2019 Gamal El-Din et al.

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Figure 5. — Graded effects of C-terminal tail truncations on late use-dependent inactivation. (A) Top: Current traces elicited by applying 100-ms depolarizing pulses from a holding potential of −180 mV to 0 mV at 0.2 Hz for different truncated constructs. Bottom: Peak inward currents measured during each train of pulses and normalized to the current produced by the first depolarization of the train for Na_VAb/WT (black, n = 7), Na_VAb 40 (red, n = 7), Na_VAb 28 (blue, n = 12), Na_VAb 10 (green, n = 5), Na_VAb 7 (yellow, n = 9), and Na_VAb 3 (gray, n = 5). (B) Top: Current traces elicited by 100-ms depolarizations from a holding potential of −180 mV at 1 Hz with different constructs. Bottom: Use-dependent inactivation profile of the different constructs during application of 100-ms repetitive pulses applied at 1 Hz. Na_VAb WT (black, n = 7), Na_VAbΔ40 (red, n = 11), Na_VAbΔ28 (blue, n = 6), Na_VAbΔ10 (green, n = 5), Na_VAbΔ7 (yellow, n = 6), and Na_VAbΔ3 (gray, n = 5). Error bars represent SEM.