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. 2019 Feb 4;151(2):118–130. doi: 10.1085/jgp.201812182

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© 2019 Abbineni et al.

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Figure 11. — Possible mechanisms by which lumenal proteins can influence the fusion pore. (A) Lumenal proteins preferentially bind and stabilize the highly curved fusion pore (shown in rectangle). (B) Lumenal proteins bind the inner leaflet of the granule membrane, giving it stiffness or rigidity that prevents expansion and flattening of the granule membrane into the plasma membrane. (C) Lumenal proteins indirectly influence the protein or lipid composition of the granule membrane during granule biogenesis, thereby altering fusion pore dynamics.