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. 2019 Feb 4;151(2):118–130. doi: 10.1085/jgp.201812182

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© 2019 Abbineni et al.

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Figure 9. — The presence of CgA slows fusion pore expansion. Chromaffin cells were transfected with NPY-EGFP + pcDNA, NPY-EGFP + CgA-HA, or NPY-EGFP + PAI. Transfected cells were stained with DiI, stimulated with elevated K⁺, and imaged using pTIRF. P/S ratios were calculated at the site of lumenal protein discharge. The length of time P/S was elevated was calculated as described in Materials and methods for n = 111 NPY-EGFP, n = 150 NPY-EGFP + CgA-HA, n = 30 NPY-EGFP + PAI and binned into three categories. A χ² test was performed to compare the distributions. ^a, significant difference between distribution of curvature durations of NPY-EGFP–containing granules and NPY-EGFP + CgA-HA–containing granules (P < 0.0001). ^b, no significant difference between distribution of curvature durations of NPY-EGFP–containing granules and NPY-EGFP + PAI–containing granules.