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. 2019 Feb 4;151(2):247–257. doi: 10.1085/jgp.201812221

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© 2019 Barro-Soria

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Figure 1. — R230C alters the voltage dependence and kinetics of KCNQ3 channels. (A) Cartoon of KCNQ3 channel representing residues mutated in this study. (B and C) Representative current traces from KCNQ3-A315T (B) and KCNQ3-A315T-R230C (C) channels for the indicated voltage protocols. Dashed line represents zero current. (D) Extrapolated tail conductances from B and C were normalized (G(V), see Materials and methods) and plotted versus test voltages (WT: KCNQ3-A315T circles; KCNQ3-A315T-R230C squares; means ± SEM, n = 7–13). For comparison, the tail conductance (dashed line) fit of heteromeric KCNQ2/KCNQ3 channel is shown. Lines represent the fitted theoretical voltage dependencies (Eqs. 1 and 2).