Figure 1.

Relationship between VRAC current activation and cell swelling in a N1E115 neuroblastoma cell. Relative cell volume is measured simultaneously with whole-cell current allowing a direct correlation between VRAC activation and cell swelling, which is the signal that activates the channel. Whole current begins to activate when cell volume has increased 10%, which is defined as the channel volume set point under these physiological conditions. Figure is modified from Bond et al. (1999).