Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 4;151(2):100–117. doi: 10.1085/jgp.201812138

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Strange et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 5. — Regulation of RVD mechanisms by intracellular ionic strength. Large fluctuations in cytoplasmic ionic strength can disrupt protein structure and function and a host of diverse cellular processes. The differential sensitivity of VRAC and the KCl cotransporter to cytoplasmic ionic strength may allow cells to reduce their volume via preferential efflux of organic osmolytes or KCl. For example, under conditions where cell swelling occurs concomitantly with elevated cytoplasmic ionic strength, efflux of KCl would serve to reduce cell volume as well as intracellular inorganic ion levels.