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. 2019 Feb 4;151(2):100–117. doi: 10.1085/jgp.201812138

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© 2019 Strange et al.

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Figure 7. — Two-dimensional structure of the LRRC8A channel. (A) Structural components of the LRRC8A protein. The protein comprises four regions, extracellular, transmembrane, intracellular, and LRR regions. β, β strand; EL, extracellular loop; H, α-helix; IL, intracellular loop; NTC, N-terminal coil; LRRCT, LRR region C terminus; LRRNT, LRR region N terminus; TM, transmembrane. Dashed lines represent protein regions that were not resolved in cryo-EM structures. (B) Subunit structure of the LRRC8A channel. The channel pore is formed primarily from ELH1, TM1 and TM2, NTC, and ILH1 and ILH3.