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. 2019 Feb 4;151(2):100–117. doi: 10.1085/jgp.201812138

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© 2019 Strange et al.

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Figure 8. — PONDR VL-XT analysis of LRRC8A (black) and LRRC8C (red) intracellular loops (ILs). PONDR scores are aligned with specific amino acid residues, which are shown at the top. Dashed box shows amino acid sequences that diverge significantly in LRRC8A, LRRC8C, LRRC8D, and LRRC8E proteins. Amino acids colored green (D182-E206) in the LRRC8A sequence are the minimal sequence required to give rise to chimeric homomeric LRRC8C-LRRC8A(IL) and LRRC8E-LRRC8A(IL) VRACs with normal swelling-induced activity. Figure is from Yamada and Strange (2018).