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. 2019 Feb 4;216(2):407–418. doi: 10.1084/jem.20181353

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© 2018 Rodriguez-Laguna et al.

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Figure 2. — Histology of GLA lesions. (A–J) Biopsies show irregular and variably sized lymphatic channels involving skin (D and I), subcutaneous fat (A and F), and soft tissues (B and G, C and H, and E and J). The endothelial cells lining the vessels show no atypical features. The lumens are empty or filled with proteinaceous fluid, occasionally containing lymphocytes and histiocytes (GLA054, asterisk). Prominent lymphoid aggregates are noted in the stroma in some cases (GLA002). The presence of hemosiderophages indicates past hemorrhage (GLA006, black arrows). In GLA053, irregular vascular channels, more evident in the superficial dermis, show intraluminal pseudopapillae (red arrow). (F–J) Immunopositivity for D2-40 (brown) highlights the endothelium of lymphatic channels. Bars, 100 µm (F, G, and J); 200 µm (H and I).