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. 2019 Feb 4;218(2):632–643. doi: 10.1083/jcb.201807124

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© 2019 Mohan et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 6. — Proposed model. Lysosomes (magenta) and autophagosomes (green) are enriched on a small subset of microtubules that are detyrosinated, where they can encounter each other, interact, and undergo fusion. KIF5B preferentially biases the localization of lysosomes to detyrosinated microtubules, where their mobility is hindered (wiggly line compared with long arrows). KIF1B, on the other hand, is more involved in lysosome motility along tyrosinated microtubules. The potential preference of KIF5B for detyrosinated microtubules and/or its hindered motility on detyrosinated microtubules may help concentrate lysosomes on this small population of microtubules, enabling their efficient fusion with autophagosomes to initiate autophagy.