Table 2. Commonly used dosages of intrapleural fibrinolytics.

Thrombolytic	Dose	Instillation	Duration
Streptokinase	250,000 IU	100–200 mL saline	Daily up to 7 d
Urokinase	100,000 IU	100 mL saline	Daily up to 3 d
tPA	10–25 mg	100 mL saline	Twice daily up to 3 d

Abbreviation: tPA, tissue plasminogen activator.

Source: Parapneumonic pleural effusion and empyema. Respiration 2008. ³⁸