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. 2018 Dec 12;24(1):159–173. doi: 10.1007/s12192-018-0953-7

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — X-ray radiographs of Manf^fl/fl Col2Cre⁻ and Col2Cre⁺ mice at 9 weeks. b Haematoxylin and eosin staining of Manf^fl/fl Col2Cre⁻ and Col2Cre⁺ cartilage growth plates at P21. c Bone measurements of Manf^fl/fl Col2Cre⁻ and Col2Cre⁺ mice at P63 showing affected endochondral ossification elements (n > 5). RZ resting zone, PZ proliferative zone, HZ hypertrophic zone. *P < 0.05, ***P < 0.0001. Scale bars 5 mm (a) and 200 μm (b)