Fig. 2.

Relationship between HSP70, hs-CRP, and HOMA-IR. Studies have already shown a correlation between HSP70 and inflammation along with a correlation between inflammation and insulin resistance, using hs-CRP and HOMA-IR as markers for inflammation and insulin resistance, respectively. Although rationally an association of HSP70 and insulin resistance might also be deduced, here, we have demonstrated an association between extracellular HSP70 with HOMA-IR even by adjustment for hs-CRP. This fact suggests a non-inflammatory role for extracellular HSP70 in driving insulin resistance