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. 2019 Jan 30;6:9. doi: 10.3389/fmed.2019.00009

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Copyright © 2019 Quitterer and AbdAlla.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A beta-arretin-biased agonist targets the AT1-B2 heteromer and promotes AT1-B2 down-regulation (right). The unbiased AT1 antagonist does not promote AT1-B2 down-regulation (left).