Table 5.

Univariate analysis of the effect of timing on physician prescribing continued LT4 vs. increasing LT4 vs. adding LT3 to LT4 vs. replacing LT4 with T3-containing therapy.

Time	Grouping of therapeutic options	Odds ratio	95% Confidence interval		P-value
March (Feb = ref)	1 vs. 2	1.03	0.8	1.4	0.83
	1 vs. 3	1.1	0.7	1.7	0.70
	1 vs. 4	0.98	0.6	1.6	0.94
Dec (Feb = ref)	1 vs. 2	1.3	0.98	1.8	0.054
	1 vs. 3	1.6	1.1	2.5	0.023
	1 vs. 4	1.6	0.97	2.5	0.062
December (Feb-Mar = ref)	1 vs. 2	1.3	1.003	1.8	0.048
	1 vs. 3	1.6	1.1	2.3	0.022
	1 vs. 4	1.6	1.01	2.5	0.045

Continuing LT4 = therapeutic group 1 (reference), Increasing LT4 = therapeutic group 2, Adding LT3 to same or reduced LT4 = group 3, Replacing LT4 with DTE or LT3 = group 4. The options in bold font have significant p-values.