Table 2.
Diagnostic performance of different indexes in the diagnosis of plTB in Wuhan cohort.
| Variable | Cutoff value | AUC (95% CI) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|
| PB T-SPOT | 6* | NA | 67.72 | 71.43 | 76.79 | 61.32 |
| PB ESAT-6 SFCs | 11.50 | 0.776 (0.714–0.838) | 48.82 | 90.11 | 87.32 | 55.78 |
| PB CFP-10 SFCs | 8.50 | 0.783 (0.722–0.844) | 52.76 | 91.21 | 89.33 | 58.04 |
| PB MAX SFCs | 14.50 | 0.779 (0.718–0.841) | 58.27 | 90.11 | 89.16 | 60.74 |
| PF ESAT-6 SFCs | 34.50 | 0.937 (0.902–0.972) | 90.55 | 92.31 | 94.26 | 87.50 |
| PF CFP-10 SFCs | 70.50 | 0.942 (0.911–0.973) | 84.25 | 96.70 | 97.27 | 81.48 |
| PF MAX SFCs | 76.00 | 0.950 (0.919–0.980) | 89.76 | 96.70 | 97.44 | 87.13 |
plTB, pleural tuberculosis; AUC, area under the curve; CI, confidence interval; ESAT-6, early secretory antigenic target 6; CFP-10, culture filtrate protein 10; PB, peripheral blood; PF, pleural fluid; SFCs, spot-forming cells; PPV, positive predictive value; NPV, negative predictive value; NA, not applicable;
*
manufacturer's cutoff value, ESAT-6 or CFP-10 ≥ 6.