Table 4.
Diagnostic performance of different indicators in the diagnosis of plTB in Guangzhou cohort.
| Variable | Cutoff value | AUC (95% CI) | Sensitivity (%) | Spesitivity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|
| PB T-SPOT | 6* | NA | 68.75 | 72.45 | 74.04 | 66.98 |
| PB ESAT-6 SFCs | 9.5 | 0.779 (0.715–0.842) | 47.32 | 91.84 | 86.89 | 60.40 |
| PB CFP-10 SFCs | 11.5 | 0.780 (0.717–0.843) | 47.32 | 90.82 | 85.48 | 60.14 |
| PB MAX SFCs | 15.5 | 0.791 (0.730–0.852) | 54.46 | 89.80 | 85.92 | 63.31 |
| PF ESAT-6 SFCs | 35.5 | 0.944 (0.911–0.978) | 90.18 | 91.84 | 92.66 | 89.11 |
| PF CFP-10 SFCs | 65 | 0.935 (0.900–0.969) | 82.14 | 94.90 | 94.85 | 82.30 |
| PF MAX SFCs | 76 | 0.961 (0.934–0.988) | 91.07 | 94.90 | 95.33 | 90.29 |
plTB, pleural tuberculosis; AUC, area under the curve; CI, confidence interval; ESAT-6, early secretory antigenic target 6; CFP-10, culture filtrate protein 10; PB, peripheral blood; PF, pleural fluid; SFCs, spot-forming cells; PPV, positive predictive value; NPV, negative predictive value; NA, not applicable;
*
manufacturer's cutoff value, ESAT-6 or CFP-10 ≥ 6.