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. 2019 Jan 30;9:3124. doi: 10.3389/fimmu.2018.03124

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Copyright © 2019 Treffers, van Houdt, Bruggeman, Heineke, Zhao, van der Heijden, Nagelkerke, Verkuijlen, Geissler, Lissenberg-Thunnissen, Valerius, Peipp, Franke, van Bruggen, Kuijpers, van Egmond, Vidarsson, Matlung and van den Berg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neutrophil ADCC and trogocytosis are reduced when afucosylated therapeutic antibodies are used. Afucosylated trastuzumab was compared to regularly fucosylated trastuzumab in both trogocytosis (A,B), and ADCC (C). Freshly isolated, 4 h and overnight stimulated (with G-CSF and IFNγ) neutrophils were combined with IgG opsonized SKBR3-SCR (white background) or SKBR3-CD47KD cells (gray background). Data shown are means + SEM with results from multiple experiments with donors ranging from N = 9–16. Statistical analysis was performed by paired t-test. ns, non-significant; ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, and ^****p < 0.0001.