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. 2019 Jan 30;10:48. doi: 10.3389/fneur.2019.00048

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Copyright © 2019 Varghese, Niewöhner, Soto-Rey, Schipmann-Miletić, Warneke, Warnecke and Dugas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview screen (left): the full examination takes approximately 20-min and starts with questionnaires and heart frequency measurement by the smartwatch. Before hand-tremor assessment starts, smart-watch calibration is required. Questionnaire screen (upper right): showing one item of the PD-NMS instrument. Initial signal processing on the smartphone (bottom right): visualization of average amplitude and frequency, raw acceleration data during examination section 3 and frequency spectrum. The acceleration data illustrates a simulated case of re-emergent tremor on the time axis. FFT, Fast Fourier Transform. Data capture and analyses of tablet-based spiral drawing is not implemented yet.