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. 2019 Jan 30;10:40. doi: 10.3389/fphar.2019.00040

Figure 1.

Figure 1

Effect of C-reactive protein (CRP) on NLRP3 inflammasome activation. HUVECs were transfected with 20 μmol/L NLRP3 siRNA, 20 μmol/L Scrarmbled siRNA for 24 h (A–E) or incubated with 20 μmol/L Z-VAD-FMK for 1 h (F–J), and then were treated in the absence or presence of 20 μg/mL CRP for 24 h. (A,B,F,G) Representative western blots showing the expression of NLRP3, pro-caspase-1, caspase-1, pro-IL-1β, and IL-1β. (C–E,H–J) Summary bar graphs showing the expression of proteins. ∗P < 0.05 vs. Scrambled siRNA or Ctr; &P < 0.05 vs. Scrambled siRNA+CRP or CRP; n = 4.