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. 2019 Jan 30;10:40. doi: 10.3389/fphar.2019.00040

Figure 2.

Figure 2

FcγRs and NF-κB are involved in CRP-mediated NLRP3 and pro-IL-1β expression. HUVECs were incubated with 1 μmol/L BAY for 1 h, and then were treated in the absence or presence of 20 μg/mL CRP for 24 h (A,C). HUVECs were incubated with 10 μg/mL CD32Ab, or 10 μg/mL CD64Ab for 2 h, and then were treated in the absence or presence of 20 μg/mL CRP for 24 h (B,F). (A,B) NF-κB activity was assayed. (C,F) Representative western blots showing the expression of NLRP3 and pro-IL-1β. (D,E,G,H) Summary bar graphs showing the expression of proteins. ∗P < 0.05 vs. Ctr; &P < 0.05 vs. CRP; n = 4.