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Cysteine proteases are associated with CRP-induced NLRP3 inflammasome activation. HUVECs were incubated with 50 μmol/L E-64d for 1 h, and then were treated in the absence or presence of 20 μg/mL CRP for 24 h. (A) Representative Western blots showing the expression of NLRP3, pro-caspase-1, caspase-1, pro-IL-1β, and IL-1β. (B–D) Summary bar graphs showing the expression of proteins. ∗P < 0.05 vs. Ctr; &P < 0.05 vs. CRP; n = 4.
