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. 2019 Jan 30;10:40. doi: 10.3389/fphar.2019.00040

Figure 6.

Figure 6

Effects of NLRP3 inflammasome on CRP-mediated LDL transcytosis in HUVECs. HUVECs were transfected with 20 μmol/L NLRP3 siRNA, 20 μmol/L Scrambled siRNA for 24 h or incubated with 20 μmol/L Z-VAD-FMK for 1 h, and then were treated in the absence or presence of 20 μg/mL CRP for 24 h. (A) Effects of NLRP3 siRNA on CRP-induced LDL transcytosis in HUVECs. ∗P < 0.05 vs. Scrambled siRNA; &P < 0.05 vs. CRP; n = 4. (B) Effects of Z-VAD-FMK on CRP-induced LDL transcytosis in HUVECs. ∗P < 0.05 vs. Ctr; &P < 0.05 vs. CRP; n = 4.