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. 2019 Jan 30;10:26. doi: 10.3389/fimmu.2019.00026

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Copyright © 2019 Kalantari, Bunnell and Stadecker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypothetical model of CD209a binding Lewis X. A model of murine CD209a was based on an existing DC-SIGNR structure (PDB 1sl6) using the Phyre2 web interface. The Lewis X trisaccharide (blue) is predicted to bind CD209a (tan). Side chains involved in calcium or sugar binding are shown. Calcium ions are shown in green; side chain oxygen and nitrogen atoms are shown in red and blue, respectively. Residues analogous to Y164 and L202 influence ligand selectivity in DC-SIGN and DC-SIGNR. In this model of CD209a, R211, and D212 are oriented toward the ligand-binding site.