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. 2019 Jan 30;9:739. doi: 10.3389/fgene.2018.00739

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Copyright © 2019 Li, Zheng, Nie, Chen, Liu, Tao, Hu, Hu, Qiao, Qi, Pei, Cai, Yu and Mou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sheepskin is an additional system to study human apocrine sweat glands. A diagram is drawn up to compare the complexity of sweat glands in human skin with those in the widely used animal models (mouse and chicken) and also in sheep used in current study. There are two types of sweat glands that exist in human skin. Eccrine sweat glands are distributed in hairless skin regions, while apocrine sweat glands are exhibited in the armpit skin. Sheep dorsal skin contains apocrine sweat glands that are similar with those of human armpit skin. Mouse dorsal skin has no sweat glands. Eccrine sweat glands exist exclusively in mouse footpad skin. Chicken skin is completely absent of sweat glands.